This symposium will explore a new approach for clinical and outcomes research that could be applicable in some countries of the region. The panel will discuss how a unique integrated dataset, including electronic health records (EHR), claims, costs, site of service, and physician linking, can improve understanding of the patient journey, inform HEOR studies, and improve clinical decision making and programs for patient care. From a payer’s perspective, one will learn how this comprehensive data helps to develop an understanding of gaps in care and the impact of a patient’s journey, their treatments, outcomes, and economics of care. From a health systems perspective, the discussion will focus on a use of the data to improve clinical decision criteria, patient management, and help design clinical quality programs and explore true clinical outcomes and comparative effectiveness.From an industry perspective, one will learn about how connecting to these unique data resources allows for a better understanding of market issues in treating patients in target therapeutic areas and allow HEOR and clinical researchers to better engage in real-world evidence (RWE), health system discussions, and collaboratively improve patient care.