OBJECTIVES::  To assess the impact of moderate-to-severe plaque psoriasis on patient health-related quality of life (HRQoL). METHODS::  This was a cross-sectional, observational and multicenter study enrolling Brazilian patients with moderate-to-severe plaque psoriasis. Data were collected between December/2015 and November/2016 in 10 specialized centers. Severity was defined according to physician evaluation. Data regarding HRQoL were obtained through two instruments: EuroQol-5D questionnaire (EQ-5D-3L) and Dermatology Life Quality Index questionnaire (DLQI). EQ-5D-3L also includes a Visual Analogue Scale (EQ-VAS), which ranges from 0 (worst imaginable health state) to 100 (best imaginable health state). RESULTS::  The study included 188 patients. Most of them were female (52.1%), Caucasian/white (68.6%) and married/stable union (61.7%). The mean age at study visit and at disease onset were 48 (±13.1) and 33 (±16) years, respectively. The leading comorbidities were hypertension (46.2%), dyslipidemia (39.3%) and psoriatic arthritis (31.0%). All patients answered DLQI and 176 (93.6%) provided valid responses for EQ-5D-3L. The mean DLQI score was 7.2 (±6.8). According to the DLQI categories, disease had no effect at all in 26.6% patients, small effect in 22.9%, moderate effect in 23.4%, very large effect in 20.7% and extremely large effect in 6.4%. The highest effect was found for “symptoms and feelings” domain (Mean 2.4 ±1.7) and the lowest in “work and school” domain (Mean 0.4 ±0.8). The EQ-5D index was 0.70 (±0.27). The dimensions “anxiety and depression” and “pain and discomfort” presented the highest quality of life impairment, in which 14.2% and 5.7% of patients reported to have extreme problems and 46.6% and 49.4% some problems, respectively. “Self-care” was the least affected dimension, with 88.1% of responders reporting absence of problems. Overall score of EQ-VAS was 68.7 (±22.3). CONCLUSIONS:: Moderate-to-severe psoriasis negatively affects Brazilian patients’ HRQoL, especially in terms of anxiety and depression as well as pain and discomfort.