OBJECTIVES: In Islamic Republic of Iran, due to increasing incidence of cancer and its high treatment costs, health sector policy makers tried to design a supportive healthcare plan. Therefore, Iran`s Healthcare reform plan has been executed since May, 2014. One of the most important objectives of this reform is equity establishment in access to health care services and financial support of incurable patients. Although chemotherapy medications are pretty expensive, no proper insurance coverage is available. This study aims to evaluate performance of healthcare reform in one of the pilot referral centers which is Imam Khomeini governmental hospital, Sari, Mazandaran in comparison to Tooba chemotherapy clinic. METHODS: In this cross-sectional research, all colorectal, gastric and breast cancer patients who were admitted between to oncology department of Imam Khomeini hospital (inpatient and outpatient) and Tooba chemotherapy clinic (outpatient), between May 1st 2015 and July 30th 2015 were enrolled to study. Final sample size was 120 patients. Statistical analysis was performed by” Instant V12.NET” software. In all cases, the value of p<0.05 was considered statistically significant. RESULTS:: There was a significant difference in terms of access to health care services (p = 0.0205) and health insurance (p<0.000) after healthcare reform among these three medical centers. Although significant difference in access to medicine between these three healthcare centers (p<0.0001), there was not any difference in drug access among outpatient and inpatient oncology department of Imam Khomeini Hospital (p=0.2182). CONCLUSIONS:: Iran `s healthcare reform was beneficial in improving health levels and increasing equity in access to chemotherapy drugs. On the other hand, geographic access, patient refers reduction and insurance coverage require more attention.