OBJECTIVES:: To evaluate the appropriateness of antibiotics used in the intensive care unit (ICU) settings of a tertiary care hospital. METHODS:: The study was of prospective type. All patients admitted in ICU, above 18 years of age, and willing to participate were included for the study. RESULTS:: A total of 117 patients were included for the study. Majority of them were males (63%). A total of 21 different antibiotics were used during their stay. The most commonly used antibiotics were cephalosporins (35%), penicillin (22%), fluoroquinolones (8%) etc. Antibiotics were started empirically in 54% of the patients. Parenteral route was the most common route for drug administration (61%). Most of the patients were prescribed two antibiotics (48%). Overall, appropriateness was found in 39% of the patients. CONCLUSIONS:: Antibiotics were found to be prescribed inappropriately in most of the patients. More adherence to the standard guidelines should be followed along with other steps such as mandatory culture test should be followed to reduce microbial resistance.