OBJECTIVES::  determining the impact generated by a drug-safety program on the emergency frequency of the target population. METHODS::  a paired samples study was conducted (1 year before and after). The recruitment period was between May 2013 and June 2015 in Antioquia, Valle, Atlántico and Cundinamarca. The population was diagnosed with persistent severe asthma. They started a pharmacological treatment with Omalizumab and education courses every month from a pharmacist of the drug-safety program (post-test). This Education was focused at proper medication usage and the importance of pharmacological adherence. Dependent variables were emergency proportion and emergency rate (number activities per each 100 patients). Absolute and relative frequencies were used, summary measure (central tendency, scatter and position). Normality test were performed (Kolmogorov-Smirnov) and association test (t-Wilcoxon y McNemar). Confidence interval 95% and standard error 5% were used. RESULTS::  : the evaluated population (n: 237) predominated for being adherent (85%), use medication correctly (90%), adults (36 [IR 19-54] years), workers (37%) or students (27%), with low schooling level (77% ≤ high school) and low socio-economic level (85% ≤ 3), from urban area (95%) from Antioquia department (91%). The 21% of patients had at least 1 emergency before and 14% after (p value: 0.045). Emergencies number per each 100 patients were 40 before and 24 after (p value: 0.04). CONCLUSIONS:: ensuring the correct usage and sufficient adherence of Omalizumab can contributed to the decrease proportion and emergencies rate of patients that assisted to emergencies service by asthma associated causes.