OBJECTIVES:: We aimed to assess the community pharmacists’ interest and attitude towards pharmacy practice-research in Ethiopia. METHODS:: A cross-sectional survey was conducted among community pharmacists in eight major cities in Ethiopia. A validated 25-item self-administered questionnaire covering interest and attitude related to pharmacy practice-research was distributed. Responses were analysed using descriptive and interfacial statistics. RESULTS:: A total of 389 community pharmacists responded to the survey (response rate- 88.4%). Most of community pharmacists showed a high level of interest in being involved in all aspects of pharmacy practice-research. Seventy percent identified ‘research advances within pharmacy field’ and more than sixty percent showed interest towards ‘generating research ideas’ (64%), ‘interpreting the research findings’ (62%), ‘reviewing scientific literatures’ and ‘giving an oral presentation’ (60%). The median summary score for interest was 38 (IQR 20-40) (range possible 11-50). More than half of the respondents showed positive attitude towards pharmacy practice-research with a median overall score of 30 (IQR 18-39), range possible 10-69. Sixty-seven percent of the respondents thought about being involved in research, felt research is important for their career (57.6%), confident to conduct the research (56.2%), and agreed that research is a part of pharmacy practice (48.5%). However, only forty-six percent agreed that they underwent research training. In multivariate analysis, a positive correlation was noticed that female gender had significantly more interest towards research than males [AOR: 1.50, 95% CI: 0.99-2.27; p<0.05]. CONCLUSIONS::  Community pharmacists showed high interest towards several areas of research competencies and demonstrated positive attitude towards pharmacy practice-research. Our findings suggests that providing research training to community pharmacists may merit in undertaking research activities and build the research capacity in Ethiopia.