OBJECTIVES::  The aim of this study is evaluate the budget impact of using point-of-care (POC) test that determine the International Normalized Ratio (INR) for patients on chronic warfarin therapy compared to centralized test in Brazil. METHODS::  A budget impact tool was developed, based on a decision tree model using peer-reviewed published data, in order to analyze the budget impact of two strategies: usual care (centralized test) and point of care test using CoaguChek XS Pro^® device (Roche Diagnostics, Basel, Switzerland), on a cohort of 1.000 patients. Additionally, the costs of diagnosis and treatment of thrombosis and hemorrhage were extracted from public data and costs published in United States Dollar were converted to 2016 Brazilian Real (BRL). The time horizon was 1 year considering Brazilian public provider perspective and a one-way sensitivity analysis was performed. RESULTS::  The budget impact tool suggested a potential saving of 59.776,11 BRL, which correspond 7% of reduction compared to the usual care. This result could be achieved due to a reduction of 14% and 11% on the treatment costs of thrombosis and hemorrhage, respectively, and an incremental of 5% on the diagnosis costs when moving from centralized test to point-of-care test. CONCLUSIONS::  An organized management with point-of-care test, for patients under chronic warfarin therapy, could lead to important savings for a Brazilian public healthcare provider due to the potential reduction of complications occurrence, such as thrombosis and hemorrhage, through increasing the number of patients within the Target Therapeutic Range (TTR) for anticoagulation.