OBJECTIVES:: To estimate the economic incremental net benefit of vaccination against infectious bovine rhinotracheitis (IBR) virus, bovine viral diarrhoea (BVD), parainfluenza 3 (PI3) virus, bovine respiratory syncytial virus (BRSV) and five Leptospiraserovars on reproductive performance in Brazilian beef herds using fixed time artificial insemination (FTAI). METHODS:: Partial budgeting was used to develop a static, deterministic, simulation model to estimate the net benefit of vaccination. Economic evaluation was applied at the herd level from the perspective of the producer. Input parameter values were based on published literature and contemporary local costs and revenues. The model was constructed to enable calculation of net benefit in the first year of vaccination (Y1) (all cows receive two vaccine doses) or second year onwards (Y2) (cows vaccinated in Y1 receive one vaccine dose, replacements receive two doses) for two typical Brazilian farm management practice scenarios: cows receive one FTAI with clean up bulls introduced 15 days later, remaining with the cows until the end of breeding season (day 120) (FM1); cows receive one FTAI, pregnancy check on day 30 with second FTAI in non-pregnant cows (11 days later), no clean-up bulls (FM2). RESULTS:: Results are presented for 100-cow herd. Vaccination yielded net benefit in Y1 and Y2 of R$4,689 and R$5,363 (scenario FM1) and R$5,839 and R$6,513 (scenario FM2). Net benefit was associated with enhanced pregnancy rate and reduced pregnancy losses leading to a reduction in the costs of FTAI (FM2 only) and increased revenues from increased number and bodyweight (a function of month of birth) of calves sold at weaning. One-way sensitivity analyses showed that the most influential input variables were revenue per kg calf sold and pregnancy rate to first FTAI in unvaccinated cows. CONCLUSIONS:: Adoption of vaccination against infectious causes of reproductive disorders in Brazilian cow-calf beef herds can yield positive economic incremental net benefit.