OBJECTIVES: As medical representative's job involves travelling, waiting, stress due to targets and extended work hours in the field, their health related quality of life may be compromised. There are no studies reporting health related quality of life, an exploratory study was done to understand factors influencing health related quality of life. METHODS: : In this exploratory study a pilot tested questionnaire was used to collect information regarding medical representatives' characteristics, demographics, work and life habits. For health related quality of life measurement both descriptive and visual analogue score of EQ 5D 5L questionnaire were used. The data collected was analyzed using SPSS 16.0.0. The test of significance was done by using Kruskal-Wallis test. RESULTS: : This is a part of large group study which is underway to record health related quality of life among medical representatives, the results presented here are of 150 medical representatives. Mean age of the population studied was 27.58±4.6, 25% having more than 4 family dependents and 53 % were science graduates. 59.3% worked for more than 8 hours per day. 45.3% were not involved in doing any physical activity. Mean BMI was 23.52±3.45 and VAS score was 84.46±12.59. There was significant difference of VAS score among the groups involved in doing and not doing any physical activity (p<0.001). CONCLUSIONS: : Even though the population studied was young, involvement in physical activity makes a difference in their health related quality of life.