OBJECTIVES: Hypothroidism is treated  by replacement therapy of levothyroxine in allopathic system of medicine needs to be taken through out life time. In Ayurveda an ethnic system of Indian medicine has a remedy based on the drugs of natural origin which showes improved thyroid function. In this study the patients are treated for Hypothroidism with combination of two proprietary medicines (Herbotrim and Muniprabha ) of Muniyal Ayurveda Pharmacy, Manipal.     METHODS: Thirty cases Hypothyroidism are selected from Inpatients and Out patients of Muniyal Ayurveda Hospital, Manipal after obtaining the consent of the patients. The study was approved by intitutional ethics committe.  The study design consited of observation before and after teatment with Herbotrim  2-0-2 (2 BID) with water and Muniprabha 1-1-1 (1TID) with water, tablets along with concomitant medicines for a period of 3 months. The  subjective Obesity, Brady cardia, Somnolence, Slow mentationand objective criteria of assessment were T3, T4,  TSH,  Hb% and cholesterol. RESULTS: The Mean palsma T3 (mcg/dl) levels were  33.4 to 105.4, T4 (mcg/dl) levels were 2.38 to 11.36 and TSH (micro IU/ml) levels were109.4 to 6.63. The hemoglobin (g%) levels were increased from 10.05 to 12.24 and serum cholesterol (mg%) leveles were dropded from 280 to 158.9.  CONCLUSIONS: Considerable improvement was observed in both subjective and objective criteria of assessment. There was decrease in subjective criteria like – Obesity, Brady cardia, Somnolence, Slow mentation, etc. There was increase in T3 and T4, and nd Hb%. The decrease in TSH and cholesterol with  Herbotrim and Muniprabha in Hypothyroidism patients.