OBJECTIVES: To study the cost effectiveness of Profofol and Thiopental Sodium in ICU wards as Induction Anesthetic. while perorming major surgery , anesthesia administration  needs an induction agent. The profofol and thiopental sodium are alternative as induction anestheatic agents. The efficacy and safety of both agents are considered almost equal.However propofol costs 248 INR (approx 4 $)whereas Thiopental is 68INR(approx 1.2 $). The variation in the price indicates that thiopental is a natural choice due to price advantage. However propofol is more popular choice of anesthesia as it is vigorously marketed. in order to establish the value of thiopental the following study was carried out.   METHODS: the study was approved by Human ethics commitee, KMC hospital, Manipal. The patients who were going on anesthesia procedure were included in the study. However the choice of the anesthetic to be used is at the discretion of the anesthesiologist. 43 patients,( propofol 34 and thiopental 19)were include in the study. The patients were administered EQ-5D and the quality of life was computed manually. Additional data on socioeconomic status was also collected in order to calculate the cost effectiveness studies.  RESULTS: The data collected was compiled and the cost effectiveness of Propofol (N=32) vs Thiopental N=19)  was calculated using EQ-5d 5L croowalk index calculator. THe EQ 5D score for Profofol was 0.228 ±0.298 and for thiopental was 0.299±0.211. the ICER was calculated using, "The average cost effectiveness = Net Cost/ Net Health Benefit" and it was found be -2535.21. CONCLUSIONS: it is found that thiopental is cost effective than propofol as ICER for the treatment is more than 2535.