CLINICAL OUTCOMES AND HOSPITAL COSTS ASSOCIATED WITH EMPIRICAL TREATMENT OF HOSPITAL-ACQUIRED PNEUMONIA WITH VANCOMYCIN OR LINEZOLID IN A CHINESE TERTIARY CARE HOSPITAL- A RETROSPECTIVE COHORT STUDY

Author(s)

Yang Y1, Song Y2, Chen W3, Liu W4, Wang K4, Li X5, Wang K6, Papadimitropoulos M7, Montgomery W8
1Eli Lilly Suzhou Pharmaceutical Co., Ltd., Shanghai, China, 2Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China, 3University of Toronto, Toronto, ON, Canada, 4Eli Lilly Suzhou Pharmaceutical Co. Ltd. Shanghai Branch, Shanghai, China, 5VitalStrategic Research Institute, Shanghai, China, 6Eli Lilly Suzhou Pharmaceutical Co. Ltd., Shanghai, China, 7Eli Lilly Canada, Toronto, ON, Canada, 8Eli Lilly Australia Pty Ltd., West Ryde, Australia

OBJECTIVES: To compare clinical outcomes and hospital costs in patients receiving empirical treatment of hospital-acquired pneumonia (HAP) with vancomycin or linezolid in Chinese patients. METHODS: Patients receiving empirical treatment with vancomycin or linezolid for HAP from 2008 to 2012 in a tertiary hospital in Shanghai were identified and linked with hospital administration databases for retrospective data extraction. Best matching pairs identified by propensity score methods for the two antibiotics were compared on HAP-related clinical response, in-hospital mortality, and allocation of hospital costs. The comparisons on clinical outcomes were confirmed by multiple logistic regression analyses with adjusting unbalanced baseline variables between matched pairs. RESULTS:

Conference/Value in Health Info

2014-09, ISPOR Asia Pacific 2014, Beijing, China

Value in Health, Vol. 17, No. 7 (November 2014)

Code

PIN14

Topic

Economic Evaluation

Topic Subcategory

Cost-comparison, Effectiveness, Utility, Benefit Analysis

Disease

Infectious Disease (non-vaccine), Respiratory-Related Disorders

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