OBJECTIVES: Current study is aimed to explore and to observe adverse drug reactions occurrence of antiretroviral drugs among HIV/AIDS patients METHODS: An observational retrospective study of all patients diagnosed of HIV infection and on HAART therapy from Jan 2007 to Dec 2012 was conducted at infectious disease department of Hospital Pulau Pinang, Malaysia. Patient socio-demographic details along with clinical features were recorded. The reported ADRs were assessed for causality by using Noranjo’s algorithm scale. Data was descriptively analyzed by using statistical package for social sciences (SPSS 20).  RESULTS: Out of 743 patients that underwent HAART therapy, 571 (76.8%) were male and 172 (23.1%) were female patients. Overall 314 (42.2%) patients had experienced adverse drug reactions. A total number of 425 (57.2%) adverse drug reactions were reported among which 311 (73.1%) occurred in males and 114 (26.8%) in female patients. Lipodystrophy 151 (35.5%) was the most common ADR reported; in male 126 (29.6%) and 25 (5.8%) female patients were recorded. Lipodystrophy was followed by skin rashes 80 (18.8%) that included 56 (13.1%) male and 24 (5.7%) female patients. Anaemia was reported 74 (17.4%), of which 49 (11.5%) observed in male and 25 (5.8%) female patients. A statistical significant relationship on Chi-square test was observed between the gender and the occurrence of adverse drug reactions (p-value =0.002). However on univariate analysis the relationship between ADRs with gender resulted in insignificant value (p-value=0.267, 95% CI= 0.862 – 1.712, Odd ratio= 1.215) CONCLUSIONS: The study indicates the incidence of adverse drug reactions is higher in male than in female patients. However, a multicenter study with a large sample size may provide us with better understanding of this relationship