OBJECTIVES: Gridhrasi(Sciatica Syndrome), Lumbar disc lesions are responsible for the disorder and observed about 25% loss of work, affects social and economic position of the individual and family. The Alopathy treatment involves symptomatic treatments  medicines by analgesics for prolonged time associated with more serious and irreversible reaction. Here we have tested a traditional approach as per principles of  Ayurveda . METHODS: The study was conducted in the OPD and IPD of MIAMS, Manipal with 3 trial groups A-Trayodashangaguggulu, B-Mustadiyapanayogabasti and C-Combined Trayodashangaguggulu and Mustadiyapana yoga basti for the period of 10 weeks in 30 diagnosed gridhrasi patients irrespective of their sex and age group18-60. RESULTS: In group A-Trayodashangaguggulu, 50.00% of patients were assessed under improved category, 10.00% each were assessed under marked improvement and moderate improvement category and 30.00% showed Unchanged. Nobody included under complete relief category. In group B-Mustadiyapana yoga basti, 90.00% of patients were assessed under improved category, 10.00% were showed Unchanged. Nobody included under complete relief, marked improvement or moderate improvement category. In group C-combined therapy of Trayodashangaguggulu and Mustadiyapana yoga basti, 50.00% of patients were assessed under moderate improvement category, 40.00% were assessed under improved category and 10.00% were showed marked improvement category. Nobody included under complete relief or unchanged category CONCLUSIONS: Study concluded all the 3 groups are effective treatment in Gridhrasi and combined therapy Trayodashangaguggulu and Mustadiyapana yoga basti was more effective and showed highly significant results in clinical symptoms of Gridhrasi and also provided highly significant result in improvingGreenough& Fraser scoring method, SLR test (Straight leg raising test), Sugar baker &Barofsky clinical mobility scale and Oswestry disability assessment questionnaire.