OBJECTIVES: The aim of this study was to describe health-related quality of life (HRQoL) of HIV-infected patients attending to a university infectious diseases clinic in Venezuela. METHODS: A sample of 82 HIV-infected HIV patients attending an infectious diseases clinic at the Central University of Venezuela was interviewed by the investigator for 20 to 25 minutes. The interview was guided by a structured questionnaire that included questions on sociodemographic and clinical characteristics, HRQoL, medication use, symptoms, and health behaviors. HRQoL was assessed using Spanish versions of  EQ-5D descriptive system and EQ visual analogue scale (EQ-VAS).  HIV-symptoms were assessed using the Adult AIDS Clinical Trials Group (AACTG) symptom scale.  Data concerning CD4-cell count and viral load was extracted from the medical records. All data analyses were performed using SSPS for Windows Version 19.0. RESULTS: Of 82 participants, 50 (61%) were male and 32 (49%) were female. The mean age was 43.33 years (Range 18-73, SD= 10.378). Concerning the EQ-5D, none subject reported problems with self-care. Three subjects (3.7%) reported some problems with mobility. Six subjects (7.3%) reported some problems with usual activity. Twenty nine subjects (35.4%) reported some problems with pain/discomfort and 28 subjects (34.1%) with anxiety/depression. Mean rate of own health on EQ-VAS was 84.77 (SD 15.927). The mean reported symptoms was 38.84 (SD = 13.08; range 21-80).  The mean CD4-cell count was 534.42 (SD = 264.02; range 75-1237). Fifty-two subjects (71.2%) had an undetectable viral load. Subjects were taking an average of 3.97 antiretroviral doses per day (SD = 1.81; range = 1-8). CONCLUSIONS: Study limitations include the sample size and the use of a convenient sample. Overall, this exploratory study demonstrates that quality of life among this group of HIV-infected patients in Venezuela was good.