Background: Latinos comprise approximately 17% of the U.S. population and that number is expected to grow at a significant rate. Spanish speaking providers are needed in many of these communities to effectively serve this population; included here is a clear demand for more clinically trained Spanish speaking pharmacists.  Only 4.1% of the students currently enrolled in U.S. pharmacy schools are Latinos. It is know that in many areas of practice, an expanded clinical role enhances patient outcomes. In most Latin American countries, the practice of pharmacy is not as clinically oriented compared to that of the U.S. Methods: We describe the intent of our university to develop bi-lingual (English and Spanish) on-line certificate programs as a method to enhance clinical pharmacy practice in Latino communities. An assessment of the needs, current practice, and future plans will be used to guide the specific program. The programs are intended to benefit pharmacists serving Latino communities in the USA as well as pharmacists serving Spanish speaking patients in Latino America as a whole. These programs will be are case-based and will require active engagement and development problem-solving skills. Certificates will first be offered in the areas of integrating culture, language, and literacy into clinical practice, basic and applied pharmacokinetics, diabetes management, hypertension management, lipid management, asthma management, anticoagulation management, appropriate use of antibiotics, and principals of herbal medicine use. The format of the case presentations will use interactive and dynamic PowerPoint slides with voice over. The certificate programs will have a pre and post-test assessment and upon completion of all the requirements, a certificate of completion will be offered by our university. Conclusion: The proposed bilingual online certificate programs could enhance clinical pharmacy practice in both U.S. Latino communities and Latino America.