Schizophrenia is a chronic, severe, and disabling mental disorder that significantly affects a person’s thought processes and emotional responsiveness. People with schizophrenia have a relatively high utilization rate of health care and mental health services.  OBJECTIVES:  To quantify the cost of schizophrenia relapse in Colombia from the perspective of the third payer. METHODS: A cost of disease study was performed including direct, indirect and transference costs of relapses in schizophrenia. Bottom-up and top down methodologies were used to obtain direct costs consumed by this population. Validation of clinical criteria took place with local KOLs for epidemiological data and resoureces estimation. Burden of disease was calculated using Disability Adjusted Life Years. The impact on the local economy was also included by obtaining transference costs. RESULTS:  There is an estimation of  714,