OBJECTIVES: To describe clinical characteristics and outcomes of patients with dengue viral infection during the course of hospitalization METHODS: During the period of three years (2011-2013) all the dengue suspected patients according to dengue suspected symptoms list were included in this study. Clinical information and laboratory parameters were collected from hospital database by using predefined data collection form. DVI was confirmed by positive IgM capture ELISA or RT-PCR RESULTS: Out of total 377 selected patients, 296 confirmed DVI (82% IgM positive, 7% IgG positive, 11% both) patients were included in this study. The mean age of the patients were 38.7 ± 11.1 years and most of them were male (79%). The fever (100%) were present in all patients while other common clinical presentations were myalgia (92%), abdominal pain (54%), nausea (73%),  and rigors (69%). According to WHO classification, dengue fever (DF) was present in 263 (89%) patients while dengue hemorrhaging fever was observed in 31 (11%) patients. Dengue shock syndrome (DSS) was found in 2 patients only. Clinical complications were observed in most of the patients that were acute kidney failure (14.1%), hepatitis (67%), respiratory failure (4.4%), seizure (2.3%), . Multiple organ failure (failure > 1 organ) was observed in 15.6% of patients. Most of clinical complications were usually associated with lower platelet count (P = 0.05), higher serum hepatic enzymes (P = 0.01) and severe forms of DVI i.e. DHF and DSS (P < 0.05). The mean days of hospitalization were 5.1 ± 1.6 days which were positively related with severe form of disease and number of complications present.  CONCLUSIONS: DVI is endemic in Malaysia with potential fatal outcomes. Signs and symptoms suggestive of dengue must be known by health care professionals to initiate adequate measures in order to reduce burden of disease in terms of morbidity, mortality and heath cost