OBJECTIVES: To develop a Brazilian Guideline on Academic Detailing (AD) – educational outreach visits to prescribers. The overall aim is to enhance the rational use of medicines and devices provided by the Brazilian National Health System (SUS).  METHODS: This document was based on an extensive search of the literature, the AD experience of international organizations and the experience of a pilot project conducted by the SUS Collaborating Centre in Belo Horizonte, Brazil. A team of 15 researches, including facilitators and coordinators of AD Programs participated in the development of this Guideline.  RESULTS: The Guideline provides an overview of the AD service that should be performed by a qualified and trained health professional (facilitator). To develop an AD Program a technical team composed of specialists on the subject to be addressed, researchers and interns should be formed. It is recommended that at least one coordinator manage the process, orient staff members, and conduct the training of facilitators. The process to develop and conduct an AD Program involves ten stages.  Stage 1: Prospection and identification of problems;  Stage 2: Definition of the AD purpose;  Stage 3: Budget estimate, elaboration of schedule and technical team designation; Stage 4: Elaboration and purchase of the support material; Stage 5: Identification of prescribers and organization of visitation goals; Stage 6: Recruitment of facilitators and workshop training; Stage 7: Prescribers’ visiting for AD; Stage 8: Release of the support material; Stage 9: Evaluation of results; Stage 10: Release of the results. CONCLUSIONS: A national Guideline is necessary to ensure the quality of AD service and the processes and outcomes that under pin it. The developed Guideline presents the main concepts of AD technique, examples of materials and forms necessary for documentation and evaluation of visits performance, and detailed information of each stage necessary to conduct an AD Program.