OBJECTIVES: Patient education is a key component for the management of acute and chronic conditions. However, majority of such educational sessions are reported from the healthcare settings. The present study therefore, aims to evaluate whether a home-based intervention can result in better understanding about Diabetes Mellitus Type 2 and can increase medication adherence to the prescribed therapies.  METHODS: A non-clinical randomized control trial was conducted whereby participants received a home-based educational intervention through a registered pharmacist. Diabetes knowledge and medication adherence were measured by means of self-administered questionnaires. Descriptive statistics were used to describe the demographic and disease characteristics of the patients. Inferential statistics were used for inter- and intra- group comparisons. SPSS 18 was used for data analysis. P<0.05 was taken as significant.  RESULTS: One hundred and fifty patients were randomly assigned to two groups (75 patients in each arm). No significant differences were observed in either group for demographic variables. There was, however, a significant increase in the participants' levels of knowledge about Diabetes Mellitus type 2 and medication adherence among the Home-based intervention group at the completion  of the intervention (p<0.001). Significantly lower HbA1c levels were also observed among the Home-based intervention group after completion of the intervention (p<0.001).  CONCLUSIONS: Pharmacist-led home-based intervention can significantly increase disease-related knowledge and medication adherence in patients with type 2 diabetes mellitus. This study hereby concludes that home-based interventional programs should be utilized as a compelling method of patient education and counselling.