OBJECTIVES: Prayers, spiritual healing, yoga, meditation, tai Chi, Qi gong, support groups are classified as Mind Body Complementary Therapies (MBCTs). While the benefits of MBCTs in cancer care is continued to be investigated, the prevalence of such practices is not well known among Malaysian cancer patients. The study aims to examine the prevalence of MBCTs use and its potential effects on Health related quality of life (HRQoL) in a group of cancer patients. METHODS: This cross-sectional study was undertaken with 393 cancer patients at the oncology wards of Penang General Hospital, Malaysia. RESULTS: Out of 393 participants, 184 (46.1%) were reported to use some type of Complementary and Alternative Medicines (CAM). Among the CAM users, 75(40.7%) patients self reported using MBCTs for their cancers. The majority of the MBCTs users were female (60/75, p=0.01), aged between 38 and 57 (44/75), and were from Malay ethnicity (46/75). Socio-demographic factors including age (r=0.15, p=0.03) and monthly house hold income (r= -0.25, p<0.001) were strongly correlated with MBCTs use. Prayers for health reasons was the highest 51 (27.7%), followed by spiritual practices 20(10.8%), meditation 7(5.9%), tai chi 7(3.8%), music therapy 4(2.1%), Qigong 1(0.5%), hypnotherapy 1(0.5%), and reiki 1(0.5%). Recommendations from friends and family members 53(70%) were the most common reasons of MBCTs use followed by patient’s own will 22(29.3%). Health related Quality of Life (HRQoL) scores shows significant difference in functional and symptoms scores among MBCTs users and non-users. CONCLUSIONS: Nearly half of the CAM users utilized some types of MBCTs. Prayers specifically for health reasons and spiritual practices are somewhat common among cancer patients. Viewing MBCTs not as alternative but to complement cancer therapies to address emotional and psychological needs may help in improving health related quality of life (HRQoL) of cancer patients.