OBJECTIVES: To assess quality of Life (QoL) among cancer patients  receiving capecitabine at Nakhon  Pathom Hospital in Thailand. METHODS: Cancer patients receiving capecitabine, either as monotherapy or in combination with other anti-cancer drugs, at Nakhon Pathom Hospital, were recruited during July to September 2011. The Thai version of the Functional Assessment of Cancer Therapy-General (FACT-G) comprising four subscales, physical well-being (PWB), social/family well-being (SWB), emotional well-being (EWB) and functional well-being   (FWB), was utilized to assess QoL of these patients. Demographic data (age, gender,status, educational level, occupation, and monthly income) as well as medical history (type, stage and duration of cancer) of the patients were also collected . RESULTS: Altogether 13 patients receiving capecitabine monotherapy and 24 patients receiving capecitabine combination therapy were recruited in this study. Their mean (SD) overall QoL score was 51.66 (9.33) from 108 . While the mean (SD) scores for PWB, SWB, EWB and FWB subscales were 8.60 (5.86), 19.91 (5.75) from 28, 7.38 (4.96) from 24 and 15.77 (7.88) from 28, respectively. The mean QoL in  this group of patients were lower than normaltive data.   Only subscal SBW that higher than normative data.  The score of BEW