OBJECTIVES: In Taiwan, the ratio of aging population is gradually increasing and nowadays the old age depression becomes a major issue of the mental disorder and integration disease prevention program. Also, the old age people always suffered from multiple chronic diseases; thus, the association of the diseases and medications could be studied in order to develop the geriatric pharmaceutical care model. METHODS: The claims database of 2000 to 2011 from the Kaohsiung Veterans General Hospital was used to select all the cases from the old age people (>65yrs.). By using the anatomical therapeutic and chemical classification system, we sort out all the depression cases of the ATC code N06A for further evaluation. All the statistical work was completed using SPSS 19.0 Base for windows.  RESULTS: There were 92,975 cases matched the acceptance criteria and a total of 10,310 patients identified in which 6836 were male and 3474 were female. The median age for male was 79 years old whereas 76 years old for female. During the 12-year study period, the median length of drug day for male was 56 days ranged from 2 to 5,276 longer than 44 ranged from 3 to 4,868 days for female. There was statistical significance difference (p<0.01) for gender using Mann-Whitney Test. CONCLUSIONS: Owing to the change from off pattern drugs to generic drugs like the selective serotonin reuptake inhibitor, Prozac, the drug fee has made a remarkable decrease during these years. Instead, the tetra-cyclic antidepressant i.e. mirtazapine and the serotonin-norepinephrine reuptake inhibitors i.e. milnacipran have increased significantly.