ONE-YEAR OUTCOMES AND PROGNOSTIC FACTORS IN SEVERE SEPSIS AND SEPTIC SHOCK SURVIVORS
Author(s)
Alkhalaf MS1, Abd.Aziz N2, Tangiisuran B3, Arabi Y4, Hassan Y51School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia, 2Universiti Teknologi MARA, Bandar Puncak Alam, Selangor, Malaysia, 3Universiti Sains Malaysia, Mnden, Penang, Malaysia, 4National Guard Hospital, King Abdul-Aziz Medical City, Riyard, Saudi Arabia, 5Universiti Teknologi MARA, Puncak Alam, Selangor, Malaysia
OBJECTIVES: To determine the outcome and the prognostic factors among severe sepsis and septic shock (SS&SK) survivors one year after hospital discharge. METHODS: This was a retrospective and cross-sectional study of patients (≥18 years) admitted ≥24 hours between April 2007 and March 2010 for the first time to the medical-surgical and trauma intensive care unit (ICU) of a tertiary hospital and discharged from the hospital alive. For patients with more than one ICU admission within the same hospitalization, only first ICU admission was counted. Data obtained from an electronic ICU database, hospital information system and medical records. Additionally, We conducted telephonic interviews to evaluate vital status and performance at one year of hospital discharge using KARNOFSKY PERFORMANCE STATUS SCALE. Patients who had cardiac arrest were excluded from the study. RESULTS: The overall mortality rate was 35%. One-third (31%) of who were still survive at one year post hospital discharge, suffer from significant (P<0.05) impairment of performance status. SS&SK survivors who had CHF had 3.4 times higher risk to die as compared to who did not had CHF. Pre-sepsis performance status and CHF were the independent prognostic factors for poor hospital outcomes on long term post hospital discharge in SS&SK survivors. CONCLUSIONS: About one third of patients die by one year, another one-third suffer from significant impairment of performance status. Pre-sepsis performance status and CHF were the independent prognostic factors in SS&SK survivors. This data highlights the need for different strategies for caring of SS&SK survivors.
Conference/Value in Health Info
2012-09, ISPOR Asia Pacific 2012, Taipei, Taiwan
Value in Health, Vol. 15, No. 7 (November 2012)
Code
PCV3
Topic
Epidemiology & Public Health
Disease
Cardiovascular Disorders