OBJECTIVES: To explore how many patients discontinue oral treatment despite satisfactory restoration of their erectile function (EF) and to identify the associated characteristics to discontinuation of medication. METHODS: Erectial Dysfunction (ED) patients treated between 2009 and 2011 in 34 urology clinics in Korea were studied. Restoration of EF after taking medication more than 4 times was asked to patients. 882 patients who reported satisfactory restoration of EF were surveyed with a questionnaire to collect data regarding patient compliance of medication, demographic, clinical, partners’ characteristics and medication discontinuation reasons. Data on ED etiology and total medication period were collected via medical chart review. We used the 857 eligible data of discriminating discontinuation. RESULTS: Total of 857 ED patients aged 53.6 ± 11.8 years had ED oral treatment for a mean period of 25.3±24.7 months. 251 (28.5%) patients discontinued oral treatment for the last one year, and patients aged < 50 years, living in rural areas and with monthly income < 4 million KRW tended to more discontinue their medication (P<0.05, respectively). Lower sexual libido, shorter treatment period, psychogenic cause of ED, and experiencing low treatment efficacy were also associated factors with discontinuation (P<0.05, respectively). Partners with characteristics of unawareness of patient’s ED treatment and experiencing poorer treatment satisfaction increased patients’ treatment discontinuation (P<0.05, respectively). Most frequent reasons for discontinuing treatment were unwillingness to have medication-dependent intercourse (31.0%), spontaneous recovery of EF (30.2%) and economic burden of medication (26.7%). CONCLUSIONS: Approximately one third of ED patients tended to discontinue the oral treatment while they reported satisfactory restoration of EF. Both patients’ and partners’ characteristics affected patients’ medication compliance in ED patient.