OBJECTIVES: Iran’s Rational Drug Use Committee (RUD) reported that antibiotics’ consumption rate has been arisen in the past decade and they were among the first five most used drugs. Irrational use of antibiotics can cause microbial resistance and move a huge part of the government financial support, this research looks forward to study about the antibiotic consumption’s in Northern states which have around 10% of the whole Iran’s population and comparing them with Iran’s total consumption to find any significant difference. METHODS: A total of 161 antibiotics are in Iran’s drugs list. According to Iran’s FDO regulations all pharmaceutical companies should report their sales statistics to this organization each month. Sales amount could be derived from this database state by state. According to WHO method, each drug ATC and DDD code have been derived. DID index (Defined daily dose /1000 Inhabitants/ Day) have been calculated according to the population of each states. RESULTS: Correlation coefficients of ascending trends of antibiotics in Northern states’ and Iran have been reported respectively as following: In oral antibiotics, four classes have significant ascending trend: Betalactams (0.715 vs. 0.693), Cephalosporines (0.99 vs. 0.989), Macrolides (0.911 vs. 0.949), Quinolones (0.897 vs. 0.9). Three classes have significant descending trend: Amphenicoles (-0.836 vs. -0.76), Sulfonamides (- 0.924 vs. -0.948), Aminoglycosides (-0.809 vs. -0.943). In parenteral antibiotics two classes have significant ascending trend: Imipenem (0.967 vs. 0.979), Macrolides (0.951 vs. 0.95). Two of them have significant descending trend: Betalactams (- 0.916 vs. -0.79), Aminoglycosides (-0.809 vs. -0.943). CONCLUSIONS: Most trends were ascending and same as the pattern of whole countries consumption. These results approve the theory of the priority in training programs to clinicians and people according to RUD’s goals in Northern states’ same as other parts of country.