OBJECTIVES: In this research, anti-inflammatory effect of Stachys Fruticulosa- M.Bieb. extract was studied in rats. METHODS: The effect of the extract against acute inflammation was studied by hind paw edema test. Intraperitoneal injection of different doses (50, 100, 200 and 300 mg/kg) of Stachys Fruticulosa which was followed by hind paw carageenan injection 1 h later were investigated. The resultant edema was quantified by measuring the hind paw edema with three ways of measurement: micrometer method, paw circumference (PC), plethysmometer method. RESULTS: After 2, 4 and 6 h we measured the anti-inflammatory effect of Stachys Fruticulosa extract. Stachys Fruticulosa extract with doses of 100, 200 and 300 mg/kg and indomethacin at a dose of 5 mg/kg showed significant effect. CONCLUSIONS: It is concluded that the methanolic extract of Stachys fruticulosa - M.Bieb. has anti-inflammatory effect which can be used as an alternative for Indomethacin for treatment of inflammation. Also it might be advantageous to use this herbal drug as a synergist for Indomethacin anti-inflammatory effects, to lower the dosage and consequently.