OBJECTIVES: To evaluate clinical pharmacist interventions in geriatric outpatients in terms of reduce the potentially deleterious consequences of polypharmacy. METHODS: This intervention study was conducted by geriatric team from March 2011 until Aug 2011 in a medical center in Taiwan. Medication assessment was undertaken in elderly outpatients aged 65 years or older who prescribed five or more drugs concomitantly on the date of inclusion. We provided Comprehensive Geriatric Assessment (CGA) to the patients. This process involves a comprehensive medication history interview by pharmacist, structured therapy assessment, and open communication between members of the medical team. RESULTS: A total of 51 patients were included during the period. The mean age was 79.4 (± 13.4) years; 53% were women. The patients took an average of 11 different long term medications. Medication reduction during 3 consequence pharmacist consulting in clinic visit were 37.7% , 38.8% , 44.2% respectively. Finally, the mean number of medications prescribed per patient was 7.8. CONCLUSIONS: Pharmacists involved in CGA has proved effective in reducing the number of prescriptions and daily drug doses for patients by facilitating discontinuation of unnecessary or inappropriate medications.