OBJECTIVES: The safety issue is an important part of medicines using besides efficacy. Once patients suffered from adverse drug reactions (ADRs), they may need for intensive care and increase the financial burden. Construction of Reporting System of Adverse Drug Reaction that let all medical care givers could report drug related adverse events, can collect the regional information and declare the analyzed ADRs to health care related professionals to prevent the unwanted events and protect patients from harms. METHODS: The data was claimed form Reporting System of Adverse Drug Reaction of a regional teaching hospital from January 2011 to December 2011. RESULTS: A total of 293 ADRs had been reported; 36.5% were female and the others were male. Analyzing by the age level, this was stratified by every 10 years, the top three were 70~79 (22.9%), 50~59 (20.1%), 60~69 (18.8%). Antimicrobial agents (28.6%) were mainly reported pharmacological catalog of suspected medicines, the second was urinary tract and sexual hormone related agents (13.0%) and the third was neurologic related agents (10.5%). Dermalogical related symptoms (29.3%) were major part of the adverse reactions and followed by nervous system related symptoms (11%) and liver related symptoms (10.4%). 55.3% are classified to type A reaction and others are type B. The causal relationships of definite, probable, possible and doubtful, sorted by Naranjo score, were 1.7%,56.9%,40.6%, and 1.7% separately. Assaying severity of ADRs, mild was 47.1%, moderate was 52.9%. Stopping the offending medicine was the most strategies to management the ADRs, followed by “stopping and giving the relief medicine” and shifting to others. CONCLUSIONS: The most offending medicines were antimicrobials agents, but health-care related professionals should observe patients’ conditions closely after taking any medicines. Building up the monitoring system is worthy to provide safety information to professionals and have the positive impact on patients. We should keep monitor that.