OBJECTIVES: To evaluate Health Related Quality of Life (HRQoL) among general population of Quetta city, Pakistan. METHODS: The study was designed as a questionnaire-based cross sectional analysis. European Quality of Life scale (EQ-5D) was used for assessment of HRQoL. A total of 1500 healthy participants from March 2011 to July 2011, aging 18 years and above were approached. Descriptive statistics were used to describe demographic characteristics of the general population. Percentages and frequencies were used to categorize the categorical variables, while means and standard deviations were calculated for the continuous variables. Inferential statistics (Mann-Whitney and Kruskal Wallis tests) were used where appropriate. HRQoL was scored using values adapted from the UK general population survey. All analyses were performed using SPSS 16.0.RESULTS: One thousand five hundred questionnaires were distributed and 1255 were returned (with response rate of 83.67%). Six hundred and forty three (51.2%) were males. Majority (n=427, 34.0%) were categorized in age group of 28-37 years. Three hundred and thirty three (26.5%) had intermediate level of education. Two hundred and ninety one (23.2%) had monthly income of in between 10001-15000 Pakistan rupees with 828 (66.0%) having urban residency. HRQoL was measured as 0.64±0.21 and VAS score was 68.71±11.71. Only age and marital status, among all demographic characteristics had significant relation with HRQoL score (p<0.05). CONCLUSIONS: Results of the present study provide the general health status of healthy population of Quetta city, Pakistan, which could sever as baseline data for further investigations.