OBJECTIVES: To analyze the treatment pattern and outcome of rodenticide poisoning in tertiary care hospital. METHODS: A retrospective observational study was carried out in a tertiary care teaching hospital on patients admitted due to rodenticide poisoning during the period of 2004 to 2012. All the patients who diagnosed with rodenticide poisoning were enrolled in the study. Patient data like demography, social habits, co-morbid diseases, pre-hospitalization period, type of exposure, type of compound consumed, type of treatment given and outcome were collected in case record form and analyzed. RESULTS: Total of 137 patients were enrolled in the study. Among them 69 (50.4%) patients were male and 68(49.6%) were female. The median age of the study population was found to be 24 (11) years. Majority of the poisoning were intentional (96%). The median pre-hospitalization period was found to be 3 (5.75) hours. Among them majority of them consumed zinc phosphide poisoning (29.2%). Treatment pattern analysis showed that majority of them received gastric lavage(48.2%), charcoal(27.7%), vitamin-k (74.5%), Fresh frozen plasma (37.2%) and N-acetyl cysteine (40.1%) as a major course of treatment. Outcome analysis showed that gastric lavage and charcoal administration was found to be beneficial as an initial course of therapy. Among the other treatment modalities N-acetyl cysteine was found to be comparatively beneficial. CONCLUSIONS: Gastric lavage and charcoal administration were found to increase the survival rate in the initial stages of management. N-acetyl cysteine was found to be more effective as a main course of therapy.