OBJECTIVES: To compare changes in blood pressure after 8 weeks of therapy between a fixed-dose combination (FDC) of amlodipine/losartan and amlodipine/valsartan using a network meta-analysis because there are no trials directly comparing amlodipine/losartan to amlodipine/valsartan. METHODS: A systematic search identified six randomized controlled trials of study FDCs and their component monotherapies; 3 included amlodipine/losartan and 3 included amlodipine/valsartan. Conventional fixed-effects methods were used to conduct the comparisons. The change in sitting diastolic and systolic blood pressure (sitDBP, sitSBP) at 8 weeks post-randomization was the primary and secondary effect measures. RESULTS: Amlodipine/losartan  5/50 mg produced greater reductions in sitDBP (-1.27 mmHg, 95% confidence interval (CI) -5.7 to 2.2) and sitSBP (-3.7 mmHg, 95% CI -9.0 to 2.9) than amlodipine/valsartan 5/80 mg. Amlodipine/losartan  5/100 mg produced a greater reduction in sitDBP (-0.45 mmHg, 95% CI -3.7 to 2.7) than amlodipine/valsartan 5/160 mg while amlodipine/valsartan 5/160 mg had a greater reduction in sitSBP (0.2 mmHg, 95% CI -6.2 to 6.0) than amlodipine/losartan  5/100 mg. The confidence of superior antihypertensive efficacy for COZAAR XQ 5/50 mg than amlodipine/valsartan 5/80 mg is 77% for sitDBP and 89% for sitSBP, while the confidence of greater efficacy for amlodipine/losartan  5/100 mg than amlodipine/valsartan 5/160 mg is 61% for sitDBP and 48% for sitSBP. With 95% CI, the reduction difference in sitDBP and sitSBP between amlodipine/valsartan 5/80 mg and amlodipine/losartan  5/100 mg is not expected to exceed 1.6 mmHg and 1.26 mmHg, respectively, and not expected to exceed 2.31 mmHg and 5.38 mmHg, respectively with amlodipine/valsartan 5/160 mg vs. amlodipine/losartan  5/100 mg. CONCLUSIONS: The blood pressure lowering effect with amlodipine/losartan and amlodipine/valsartan was comparable. The findings from this network metaanalysis do not indicate a potential superiority of the reductions realized with amlodipine/valsarta relative to amlodipine/losartan.