OBJECTIVES: Burmese laboures are major Non-Thai patients in Samutsakhon Hospital. Culture and language barriers between Samutsakhon Pharmacist  and Burmese patients may lead to  many drug related problems that effect to patients safety .For this reasons, Burmese transalators were worked  like pharmacists assistants since May 2008. This activity may improve quality of service as increased cost.This research is aim to determine labor cost of Burmese translators at pharmacy department ,Samutsakhon Hospital METHODS: This research is descriptive study in health care provider prospective to determine labor cost of Burmese translators between October 1, 2009 to December 31, 2009. Unit cost of Burmese translator was calculated from  labor cost  multiply with estimated time in each translator activities by observation . RESULTS: The results of this study found that labor cost of Burmese translator is 0.98 bath / min , and unit cost of each activity included translating drug information for general patients costs 2.45 bath / case  ,while, dispensing vitamins for Burmese pregnancies which costs about 0.98 bath / case.  Although giving drug information for TB and AIDs patients is 4.9  bath / case or translating  the evaluating adverse drug reaction  is 9.8 bath / case. The most expensive cost is teaching to use special device for asthmatic patients about 14.7 bath / case .There are other assignments , for example, preparing Burmese drug leaflets or prepack  medicines .Every activities are under  responsibed by  Thai pharmacists. CONCLUSIONS: From this study is quite similar to labor cost of Nurse assistants at  Ledsin Hospital, Bangkok in 2005 (0.81 bath / min) .Also, this information can be applied for other hospitals that in the similar situation . This study can  help decision- maker to spend more budget  to  improve quality of  pharmaceutical care with humanity.