OBJECTIVES: To determine health related quality-of-life (QoL) of patients diagnosed with genital warts, cervical cancer and cervical intraepithelial neoplasia (CIN), compare QoL across genital warts, CIN1, CIN2/3 and stages of cervical cancer and to study association between QoL and general characteristics of patients. METHODS:  The cross-sectional descriptive study was conducted at the King Chulalongkorn Memorial Hospital using a standard questionnaire. The questionnaire elicited information on general patient characteristics such as age, occupation, and educational attainment, and on QoL using Functional Assessment of Cancer Therapy-General (FACT-G) questionnaire. The study population were patients with a diagnosis of one of the four FIGO stages of cervical cancer, cervical intraepithelial neoplasia low-grade (CIN1) or cervical intraepithelial neoplasia high-grade (CIN2/3) or genital warts as confirmed by physical and pathological examination. RESULTS:  A total of 197 patients completed the study questionnaire with a diagnosis of genital warts (n=25), CIN1 (n=25), CIN 2/3 (n=25), IA1 (n=25), IA2 IB IIA (n=37), IIB-IVA (n=32) and IVB (n=28).  The mean age was 47.3 years and majority were housewives with educational attainment of primary school or lower. The adjusted mean scores were as follows: global QoL 78.08 (95%CI=76.4, 79.8); physical wellbeing, 81.9 (95%CI=79.6, 84.3); social well-being, 72.5 (95%CI=70.1, 74.9); emotional well-being, 78.7 (95%CI=76.3, 81.2); functional well-being, 79.3   (95%CI=76.9, 81.7). There were no significant differences between stages of diseases and global QoL or subscales. We found a positive association between age and emotional well being scores (p=0.001). Lower educational attainment was associated with higher emotional well being scores (p=0.049). CONCLUSIONS:   Our finding shows that, impact of QoL on disease of CIN or genital warts did not differ from cervical cancer. Young HPV related-disease patients and those with higher education may experience emotional difficulties. Social, family or religion support may be considered for these patients.