OBJECTIVES: To assess the satisfaction and health-related quality of life (HRQoL) improvement of patients enrolled in a pharmacist-run Methadone Maintenance Therapy (MMT) programme. METHODS: A cohort study design was used to measure satisfaction and to evaluate changes in HRQoL of patients after one month of receiving methadone treatment at Taiping Health Clinic. Respondent’s satisfaction was measured by using an 8-item pre-validated questionnaire. A post-survey reliability analysis of the questionnaire showed a high internal consistency of the items (Cronbach Alpha = 0.785). Meanwhile, the HRQoL was measured using a validated EQ-5D and EQ-VAS questionnaire that are administered by face-to-face interview in two phases, after one month interval. The data were analyzed by using both descriptive statistics (frequencies and percentages) and inferential statistics (Χ2 test, paired t-test and the McNemar Χ2 test). RESULTS: All 54 patients in MMT clinic participated, but only 40 (74.1%) completed this study. Average methadone dose in both phases were low (Phase One = 37.4 mg [SD=22.2], Phase Two = 44.4 mg [SD=21.3]) that caused majority of respondents wishing to increase their current dose. Respondents were not satisfied with needs to come clinic daily (n=18, 33.4%) and did not believe that MMT clinic can help in cessation of drug abuse (n=9, 16.7%). These two items were significantly associated with travelling distance of respondents to clinic (p=0.001 and p=0.039, respectively). Only pain/discomfort domain of the EQ-5D showed a significant improvement from the baseline (p=0.035). EQ-VAS score significantly improved from 64.69 (SD=16.7) at baseline to 71.43 (SD=14.9) during the one-month follow-up (p=0.008). CONCLUSIONS: MMT programme was able to improve patients’ QoL even in short duration of time. Improvement on dissatisfactions towards travelling distance, needs to travel daily to clinic and inadequate dose will help to increase treatment success.