OBJECTIVES: The study aimed to assess the clinical and socio-demographic factors associated with pulmonary and extra pulmonary tuberculosis in Yemen. METHODS: A cross-sectional study was carried out among 160 Pulmonary Tuberculosis (PTB) and 160 Extra Pulmonary Tuberculosis (EPTB) patients diagnosed and treated in a TB center in Sana’a, the capital city of Yemen. Socio demographic, clinical and laboratory data and types of drug regimen used in treatment were collected from TB patients and medical records from the TB center. Risk factors for EPTB patients and PTB patients were identified through structured questionnaire by interviewing.   RESULTS: The female to male ratio was 1.2 and 1.6 for PTB and EPTB, respectively. The median age for PTB patients was 28 and 30 for EPTB patients. It was also found that the TB patients with low educational level amounted 52% and 49% in PTB and EPTB respectively. This study illustrated that the majority of smokers were males 64% for PTB and 58% for EPTB, whose age ranging between 15-54 in both PTB and EPTB cases. This study found the extra pulmonary tuberculosis patients diagnosed in private hospital and clinics (41%) more than pulmonary tuberculosis patients (26%) There were significant differences in vaccination in case of employed patients of PTB than non employed patients and educated patients of PTB than non educated patients (P=0.02 and P= 0.036) respectively. There was also significant difference in vaccination in case of employed patients of EPTB than non employed patients (P<0.0001). CONCLUSIONS: In conclusion, female and younger ages were higher in both EPTB and PTB. The EPTB patients diagnosed in private hospital and clinics were more than PTB patients. The EPTB patients have less monthly income than pulmonary TB.  Vaccination has strong correlation with education and employment in case of PTB & EPTB patients.