OBJECTIVES: To compare the utility scores of hemodialysis patients obtained from the EQ-5D (Euroqol), VAS (Visual Analog Scale), and SF-6D (Short Form-6 Dimensions which developed from SF-36) and to analyze the relationship between the utility scores and the HRQoL scores using KDQOL-SF (Kidney Disease Quality of Life Short Form) disease specific questionnaire.  METHODS: This study was a cross-sectional study. Face-to-face interview included KDQOL-SF (consist of SF-36 and kidney disease questionnaires) and EQ-5D was conducted during November-December 2009 with 155 patients receiving hemodialysis at Siriraj hospital.  Not only the correlation coefficient was compared across the different measurement tools but the Bland and Altman plot was also used to graphically illustrate the agreement of instruments.  RESULTS:  Patient samples had the mean age of 57.28±14.49 years and been hemodialised on the average for 7.70 ± 5.07 years.  The mean SF-6D score was 0.749±0.139 showing significantly higher than EQ-5D (0.686±0.322), and VAS (0.654±0.310) scores. The Pearson’s correlation coefficients between utility scores with kidney disease specific questionnaires illustrated that all three utility scores correlated well with the dimension of Symptoms and Problems, but were low associated with Burden of Kidney Disease and Effects of Kidney Disease on Daily Life dimensions.  Of these 3 disease specific dimensions, the SF-6D showed higher relationship on 2 dimensions. The Bland-Altman plots also suggested a pattern of agreement in favor of SF-6D with kidney specific dimensions.  CONCLUSIONS: Utility scores from SF-6D, EQ-5D, and VAS illustrated consistent results with highest score on SF-6D.  The SF-6D presented better agreement with kidney specific scales than EQ-5D and VAS.  These findings implied that SF-6D could, to a certain extent, reflect HRQoL status of hemodialysis patients and might be use as the only QOL instrument for patient care to avoid patients’ burden on answering multiple questionnaires.