OBJECTIVES: To assess the knowledge and perception of community pharmacists in Malaysia towards reporting of adverse drug reactions (ADRs). METHODS: A Cross-sectional study employing pre and post intervention design was undertaken with a sample of 42 community pharmacists to explore their knowledge of and the perception towards the pharmacovigilance and ADRs reporting. Changes in scores before and after the completion training program in knowledge and perception were measured. Statistical analysis: The data were analyzed by using SPSS version 17.0 software package (SPSS Inc., Chicago, IL, USA). Both descriptive and inferential statistics were used when ever appropriate. Frequencies and percentages were used to describe the respondents’ demographic information and professional characteristics. Wilcoxon Signed ranks test, Paired sample t test and The McNemar χ2 test were applied to compare the differences in knowledge and perception before and after the educational program whenever appropriate. RESULTS: Forty-two community pharmacists (CPs) were enrolled in this study. A comparison of CPs knowledge before and immediately after implementation the education program showed significant differences ,the participated community pharmacists’ mean scores in knowledge of pharmacovigilance and adverse drug reactions reporting significantly increased compared to the baseline (z = -5458,N= 42 p<0.001). Following the intervention, only few (3, 7.2%) respondents reported that they do not have any ideas on how to report ADR to the relevant authorities in Malaysia. Upon completion of the education program, a large proportion of the pharmacists (45%) believed that they were confident in their knowledge in detection and performing ADRs reporting (z = -2.866, N=42, P = 0.004). CONCLUSIONS: The finding of the study indicates the need for designing educational programs for the community pharmacists, in order to improve the level of knowledge towards the pharmacovigilance and ADRs reporting process locally.