OBJECTIVES: Understand the Brazilian set needs about HTA and Health economics METHODS: In deep interview, based on a structured questionnaire, with decision makers from the public and private set, Prescriptors, Patients group and Manufacturers.   RESULTS: a total of 131 interviews was conducted: 60 decision makers, 50 Prescriptors, 10 patients groups and 11 manufacturers. For the decision makers and Manufacturers, HTA and Health economics its’ a main issue and, despite several methodological mistakes, takes an important role on the decision and business. Patient groups and prescirptors are not very well awarned about the issues in analysis, but consider that a better knowledge about is important and can be very useful for the prescriptor and patients. For all the stakeholders, education and access to clear information was a main issue of need. CONCLUSIONS: Considering the rich database that this research provides and the knowledge about the needs and points to enforce, ISPOR Brazil will be able to act with more focus.