OBJECTIVES:This study aims to evaluate quality of life for patients receiving oral anticoagulation. A comparison was also made between the first visit time and at 4-month follow-up in the anticoagulation clinic. METHODS:The patients receiving oral anticoagulation treatment referred to anticoagulation clinic by physicians at outpatient department. The pharmacist provided pharmaceutical care to these patients and continued to follow up. Both Taiwan version of treatment-related quality of life questionnaire and RAND 36-Item Health Survey 1.0 (RAND-36) were administrated to them in the first visit time and at 4-month follow-up. The treatment-related quality of life questionnaire was translated into Chinese from its English version developed by Dr. Sawicki. The treatment-related quality of life questionnaire covered the following psychological domains: medical treatment satisfaction, self-efficacy, strained social network, daily hassles, and general psychological distress. RESULTS: A total of 114 patients receiving oral anticoagulation treatment were referred to anticoagulation clinic. The treatment-related questionnaire and RAND-36 Survey were completed by 78 patients both at baseline and 4-month follow-up. The response rate was 68.4% (78/114). In Rand 36-Item health survey, five domains had significant difference which were role functioning (44.35±30.08 vs. 75.0±0.45; p=0.01), social functioning (78.29±17.10 vs. 89.38±13.00; p=0.03), energy (49.47±17.47 vs. 70.00±16.14; p<0.01), mental health (59.58±19.64 vs. 72.20±19.53; p=0.05) and general health (49.47±20.26 vs. 69.25±20.34; p<0.01). In the treatment-related quality of life questionnaire, two domains had significant difference which were self-efficacy (3.32±0.86 vs. 4.80±0.57; p<0.01) and daily hassles (2.96±0.76 vs. 2.41±0.78; p=0.03). CONCLUSIONS: The results demonstrated that quality of life for patients receiving oral anticoagulation is significant improvement after pharmacist providing pharmaceutical care.