OBJECTIVES:  Hospital readmissions can be proxy of poor health and quality. Reducing readmission rates has been a priority for healthcare providers and payers. We examined the trend over time in 30-day all-cause readmission rates among patients with AMI in a large, single healthcare network of 11 hospitals in the Chicagoland area. METHODS:  AMI patients admitted from 2008 to 2016 who were 18 years or older, discharged to home self-care, home health, or home infusion were included in the analysis. Adjusted logistic regression with Generalized Estimating Equations was used to account for clustering of multiple admissions within patients. Additionally, the model adjusted for age, gender, race, insurance, length of hospital stay, and discharge disposition. RESULTS:  Records of 15,243 patients were analyzed and it was determined that 10% of these patients were readmitted within 30 days.The Majority of the patients in the sample were males (62%), primarily White (60%), and were discharged to home (76%).The Average age of the sample was 65 years (±13.7) and more than half (55%) had public insurance (i.e., Medicare & Medicaid). Patients who were readmitted were slightly older (67 vs 65 years) and had longer length of stay (5 vs 4.1 days). Females, patients with public insurance, and those who were discharged to home health were more likely to be readmitted. A significant downward trend over time was observed in 30-day readmission rates in the fully adjusted model (OR=.96; CI=.94 –.97). CONCLUSIONS: We found a significant reduction in 30-day readmission rates over time between the years 2008 and 2016. This reduction is substantial as it reduces both physical and economic burden of readmissions on our patients and healthcare system and remains a significant quality measure closely linked to incentives and penalties for care providers by the private and public payers.