OBJECTIVES: To systematically review the effectiveness of e-health (use of information and communications technology for health) in improving adherence to inhaled corticosteroids (ICS) among patients with persistent asthma, as well as the satisfaction of patients undergoing e-health interventions. METHODS: Literature searches were conducted in PubMed, CINAHL, Academic Search Premier, PsycINFO, and the International Pharmaceutical Abstracts databases in October 2016. Additional articles were identified by hand-searching, and from clinicaltrials.gov. Included studies were randomized controlled trials comparing e-health interventions versus usual care in improving adherence among patients taking ICS for persistent asthma. Quantitative synthesis was performed using a random effects model. RESULTS: Eighty records were identified after duplicates were removed. Of these, 15 trials including 13,907 participants were eligible for qualitative synthesis. Subsets of e-health trials included - social media (1), electronic health record (1), telehealth (6), and mHealth (7). Only 6 out of 15 trials were eligible for quantitative synthesis, including 3 telehealth and 3 mHealth trials. Results show an insignificant overall effect of e-health interventions on the improvement of adherence to ICS. However, a significant improvement in adherence was observed for mHealth interventions compared to usual care in a pooled analysis of 3 trials (SMD 1.29; 95% CI 0.43 to 2.14). We considered the risk of bias in included studies to be low, however, there was considerable heterogeneity among studies (I = 89%). Patient satisfaction was evaluated in 6 trials comparing telehealth (2) and mHealth (4) with usual care. Moderate satisfaction was reported in 1 study and high satisfaction in 5 studies. CONCLUSIONS:  Among e-health interventions, mHealth interventions were found to be effective and acceptable in improving adherence to ICS. However, there is a need for more studies to evaluate the effectiveness of more e-health interventions in increasing adherence to ICS. Future studies should examine patients’ satisfaction with these interventions.