OBJECTIVES: Background: Required public reporting and reimbursement penalties have contributed to the increased focus by hospitals to reduce hospital-acquired infections (HAI). Although management of HAI requires a multidisciplinary approach, we explore the different roles and contributions of hospital pharmacists to summarize approaches that could be adopted by pharmacists and pharmacy directors in other institutions. METHODS: Face-to-face guided interviews of eight pharmacists from eight different hospitals were conducted on the role of pharmacists in addressing HAI. The interviews were transcribed and summarized using NVIVO thematic analysis. RESULTS: The most common HAI reported by the pharmacists was Clostridium difficile