OBJECTIVES:  The coherence-feeling is the main element of salutogenesis which is a valid factor of health. The different work schedule influences the nurses circadian rythm and health condition. The aim of this research is to find the least stressful work schedule, to measure the health status and coherence-feeling of the nurses. METHODS:  During the quantitative, cross-sectional research we used convinient sampling method to take the datas from four hospitals of the Southern Transdanubian region and in the breaks of the advanced trainings held by the Faculty of Health Sciences, University of Pécs. Altogether 355 nurses from standard departments filled the Sense of Coherence questionnaire. Data were analysed with t-test, chi-square test, ANOVA, Kruskal-Wallis and linear regression in SPSS 22.0. RESULTS:  The 76.6 % of the responders thought that the irregular work schedule is more stressful than the regular ones. Out of the regular work schedules the best is: 1 daytime shift followed by 1 night shift and 2 days of break (62.5 %). The average point of the coherence-feeling is 61.76. The coherence-feeling of those who work in daytime shift is better than those work in shift work (t=2.933; p=0.004). Irregular work schedule nurses’ coherence-feeling is lower than the flexible shift workers’s (p=0.04). The most favourite regular multiwork schedule workers’ coherence-feeling is higher than the secondly more frequent regular schedule workers’ (p=0.022). Ppsychosomatic symptoms incidency is higher among nurses working in shift work than working in daytime work schedule (p=0.031). CONCLUSIONS:  The irregularity of the work schedules are very stressful for nurses. Because of the health condition of the nurses- and the patient care- it is really practical to create the less stressful work schedule.