OBJECTIVES: To assess hypertension-related knowledge among patients pursuing complementary and alternative medicines (CAM) as a way of self-care; and find the differences in patient’s knowledge following educational intervention. METHODS: The study was conducted between May to December 2015 among hypertensive patients attending two major teaching hospitals in Baghdad, Iraq. A cross-sectional design was adopted; and a convenience sampling technique was used for patients’ recruitment. Data collection based on the use of standard validated questionnaire for patient assessment on enrollment and follow-up clinical visit thereafter. Patients were engaged in two separate CAM education sessions and a four-page booklet was used for the purpose of education. RESULTS: Inadequate knowledge towards hypertension (mean=6.94+3.2) was prevalent among the respondents. A significant difference in hypertension-related knowledge was seen among CAM users and no-users (P=0.007). Where, CAM users were less (mean=6.69+3.3) in their level of hypertension-related knowledge than CAM non-users (mean=7.6+3.4). This was affected by demographic characteristics like gender (P=0.004), education (P<0.001), monthly income (P=0.002), and marital status (P=0.003). However, a significant improvement in patients’ a knowledge was detected following the enrollment in the education program (P<0.001). CONCLUSIONS:  Hypertension-related knowledge was inadequate among Iraqi hypertensive patients pursuing CAM as a way of self-care. This poor knowledge among CAM users was affected by diverse patient’s characteristics like gender, education, monthly income, and marital status. A significant improvement in hypertension-related knowledge was seen following the educative information. The education program was effective and provide reliable information for the purpose of patient’s education in the context of CAM.