OBJECTIVES: Study of co-morbidities in patients with type II diabetes mellitus is important as co-morbidities increase the disease burden and cost. It results in poor quality of life and reduced life expectancy. Studies have shown that diabetes is associated with different diseases such as hypertension, cardiovascular diseases, chronic kidney disease, dyslipidemia, tuberculosis, anemia, depression etc. METHODS: The study was of prospective and observational type. It was conducted in a teaching hospital in South India for a period of 5 months from July 2016 to November 2016. All the patients diagnosed with type II diabetes mellitus with medical history of it since more than 1 year were included in the study. RESULTS: Out of the total 62 patients, majority (56%) were males. The median age was 52. Majority of the patients (27%) had a single co-morbidity, 18% had two co-morbidities and very few patients had three or more co-morbidities. Hypertension (38%) was the most common co-morbidity. Other co-morbidities found were cardiovascular diseases (11%), chronic kidney disease (9%), depression (6%), tuberculosis (6%), anemia (4%) hypothyroidism (3%) etc. CONCLUSIONS: Co-morbidities were common in patients with type II diabetes mellitus. Proper selection of antidiabetic drugs considering co-morbidities can provide better outcome and prevent further complications in patients.