OBJECTIVES: Simultaneous endovascular aneurysm repair (EVAR) and coronary artery bypass grafting (CABG) includes two different surgical operations doing by two teams of operating surgeons during one anaesthetic support. Patients with concomitant aortic aneurismal disease and coronary artery disease stay in group of high risk of perioperative aortic aneurism rupture and myocardial infarction. Therefore, simultaneous EVAR/CABG can reduce the incidence of late aortic aneurism rupture and myocardial infarction and can improve survival in the short and long-term period. This research aim is to evaluate clinical effectiveness, safety and economic effectiveness of simultaneous EVAR/CABG compared with conducting these surgical operations separately. METHODS: For opportunity to evaluate clinical effectiveness, safety and economic effectiveness of simultaneous EVAR/CABG the systematic literature search was conducted in databases of evidence-based medicine named MEDLINE, EMBASE, Tripdatabase, Clinical Trials. Publication date: no later than 10 years (since 2007). RESULTS: As a result of systematic search we found 12 articles; all of these articles confirmed clinical effectiveness and safety of simultaneous EVAR/CABG in patients with large and/or symptomatic aortic aneurism and severe coronary artery disease. Simultaneous EVAR/CABG can be viable procedure with low operative mortality and acceptable rate of perioperative complications. From the side of economic effectiveness conducting simultaneous EVAR/CABG can reduce costs for 1 patient treatment by a mean of 7.5% (1 120 USD) due to 1) reducing duration of hospital stay and postoperative rehabilitation; 2) no need for additional anaesthetic support; 3) decreasing in incidence of post-operative aortic aneurism ruptures and myocardial infarctions in patients with concomitant aortic aneurismal and coronary artery diseases. CONCLUSIONS: Simultaneous endovascular aneurysm repair and coronary artery bypass grafting can be viable procedure for patients with concomitant large and/or symptomatic aortic aneurism and severe coronary artery disease with low operative mortality, acceptable rate of perioperative complications and has some economic advantages over conducting these surgical operations separately.