RISK OF INCIDENT UVEITIS IN PEOPLE WITH PSORIASIS- A NATIONWIDE COHORT STUDY
Author(s)
Chi C1, Wang J2, Lin Y3, Chen Y4, Hsu T5, Wang S6, Tung T5
1Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan, 2National Taiwan University, Taipei, Taiwan, 3Chang Gung Memorial Hospital, Chiayi, Puzih, Taiwan, 4Taipei City Government, Taipei, Taiwan, 5Cheng Hsin General Hospital, Taipei, Taiwan, 6Far Eastern Memorial Hospital, New Taipei, Taiwan
OBJECTIVES: To evaluate the risk of uveitis in people with psoriasis. METHODS: We used Taiwan’s National Health Insurance Research Database to conduct a retrospective cohort study, and identified 147,954 people with psoriasis (including 10,107 with concomitant psoriatic arthritis and 137,847 without psoriatic arthritis) and 147,954 nonpsoriatic controls. We used the Cox proportional hazard model to assess the hazard ratio (HR) for incident uveitis in people affected by mild and severe psoriasis with and without psoriatic arthritis with reference to nonpsoriatic controls. RESULTS: The severe psoriasis with psoriasis arthritis group had the greatest risk of incident uveitis in comparison to nonpsoriatic controls (adjusted HR 2.40 (95% confidence interval (CI) 1.90‒3.02)). The severe psoriasis without psoriasis arthritis and mild psoriasis with psoriasis arthritis groups also had an increased risk of incident uveitis (adjusted HR being 1.42 (95% CI 1.23-1.64) and 1.42 (95%CI 1.03-1.96), respectively). On the other hand, the mild psoriasis without psoriatic arthritis group did not have an increased risk for incident uveitis (adjusted HR 1.09 (95% CI 1.00‒1.20). CONCLUSIONS: People with severe psoriasis and those with mild psoriasis but with psoriatic arthritis have an increased risk of uveitis. Clinician may use this finding as a guide for uveitis risk stratification in patients with different inflammatory presentations on the spectrum of psoriatic disease.
Conference/Value in Health Info
2017-05, ISPOR 2017, Boston, MA, USA
Value in Health, Vol. 20, No. 5 (May 2017)
Code
PSS2
Topic
Epidemiology & Public Health
Disease
Sensory System Disorders