OBJECTIVES:  To estimate the prevalence and study e-cigarette (e-cig) user characteristics among Chronic Obstructive Pulmonary Disease (COPD) patient population in the United States. METHODS:  The National Health Interview Survey (NHIS) 2014 data were used to generate weighted prevalence estimates among the US adult civilian noninstitutionalized population with age ≥ 18 years (Weighted N = 239,688,457). COPD individuals were those who responded yes to the question “Have you ever been told by a doctor or other health professional that you had chronic obstructive pulmonary disease, also called COPD?”. Current e-cig users were the one using e-cig devices for either every day or some day while ever e-cig users were those who had ever used e-cigs even once. E-cig user characteristics among COPD subjects evaluated were age, sex, race, census region, marital status, current working status, type of employment, number of current jobs, smoking status, BMI, current use of combustible or smokeless tobacco products, and quit attempts over the past year. Chi-squared tests were used to compare the data. All our analysis employed NHIS sampling weights to generate data representative of the entire US population. RESULTS:  Weighted prevalence estimates for current and ever e-cig users among COPD subjects were 8.64% (Weighted N = 642,848) and 24.37% (Weighted N = 1,793,828) respectively. Among current e-cig users with COPD, proportion of use were found to be higher (P < 0.05) for ages 45 to 64 years age (56.96%), divorced (30.75%), residents in the south region (53.88%), unemployed (87.50%), dual users of other tobacco products (68.48%), and individuals who have tried quitting tobacco use at least once in past 12 months (62.20%). CONCLUSIONS:  Awareness and use of e-cigs have not just increased in general population, but its uptake has also increased in the COPD disease population. Usage was higher among current smokers and those who wanted to quit tobacco.