OBJECTIVES: The present study aimed at assessing the prevalence and correlates of herbal medicine use among pregnant women on ANC follow-up at Gondar university referral hospital, Ethiopia. METHODS: An institutional-based cross sectional study was employed on 364 pregnant women attending ANC clinic from March to May 2016 at Gondar university referral hospital, northwest Ethiopia. Data on socio-demography, pregnancy related information as well as herbal medicine use was collected through an interviewer-administered questionnaire. Descriptive statistics, univariate and multivariate logistic regression tools were used to analyze with the prevalence and correlates of herbal medicine use. RESULTS: From 364 respondents, 48.6% of them used herbal medicine during current pregnancy. Ginger (40.7%) and Garlic (19%) were the two most commonly used herbs in pregnancy. Common cold (65%), constipation (14.7%) and inflammation (13%) were the most common reasons for herbal use. Majority of herbal medicine users (89.8%) have not consulted their doctors about their herbal medicine use. Average monthly income less than 100 USD (AOR: 3.079 95 % CI: 1.221-7.767) were found to be strong predictors of herbal medicine use. CONCLUSIONS: The use of herbal medicine during pregnancy is a common practice and associated with being rural residency, illiteracy and low average monthly income. Given the high frequency of herbal medicine and a very low disclosure rate, health care providers should be open to discuss the use of herbal medicines with their pregnant women as it will lead to better health outcome.